The synthesis and natural distribution of the major ketone constituents in Echinacea pallida.
نویسندگان
چکیده
The first synthesis of a series of ketones naturally occurring in E. pallida is described. The natural distribution of these ketones among different Echinacea species is also reported.
منابع مشابه
Echinacea sanguinea and Echinacea pallida extracts stimulate glucuronidation and basolateral transfer of Bauer alkamides 8 and 10 and ketone 24 and inhibit P-glycoprotein transporter in Caco-2 cells.
The use of Echinacea as a medicinal herb is prominent in the United States, and many studies have assessed the effectiveness of Echinacea as an immunomodulator. We hypothesized that Bauer alkamides 8, 10, and 11 and ketone 24 were absorbed similarly either as pure compounds or from Echinacea sanguinea and Echinacea pallida ethanol extracts, and that these Echinacea extracts could inhibit the P-...
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Because of the popularity of Echinacea as a dietary supplement, researchers have been actively investigating which Echinacea constituent or groups of constituents are necessary for immune-modulating bioactivities. Our prior studies indicate that alkylamides may play an important role in the inhibition of prostaglandin E2 (PGE(2)) production. High-performance liquid chromatography fractionation,...
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Background: Echinacea is a plant that has been widely used for its’ medicinal properties, which include antioxidant properties, immune-stimulant, and antiinflammatory properties. In this study, the effects of extracts of Echinacea pallida, Echinacea purpurea as well as the standard components of Echinacea were observed on a breast cancer cell line (BT-549). Also the effects of extracts of Echin...
متن کاملEthephon Can Overcome Seed Dormancy and Improve Seed Germination in Purple Coneflower Species Echinacea angustifolia and E. pallida
Low and erratic seed germination presents a major production problem in the medicinal plants that collectively are called echinacea or purple coneflower (Echinacea angustifolia and E. pallida). In this study, nine seed lots of each E. pallida and E. angustifolia from a wide variety of commercial sources and germplasm collections were collected and treated with a solution of 1.0 mM [144.5 mg·L-1...
متن کاملIsolation, structure elucidation and total synthesis of a cytotoxic dienone from Echinacea pallida.
The isolation and structure characterization of a dienone from the roots of Echinacea pallida, namely (8Z,11Z)-pentadeca-8,11-dien-2-one, are described here. To assess the configuration of this secondary metabolite, the stereoselective total synthesis of the two isomeric forms, (8Z,11Z)- and (8Z,11E)-pentadeca-8,11-dien-2-one, was undertaken and the structure elucidation of the natural compound...
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ورودعنوان ژورنال:
- Molecules
دوره 12 3 شماره
صفحات -
تاریخ انتشار 2007